张丰 | 生物统计学博士

海南比勒费尔德应用科学大学

副教授, 电子信息科学与技术学科带头人

工作：海南比勒费尔德应用科学大学，电子信息科学与技术学科带头人。曾任上海交通大学医学院副研究员，合作PI为李令杰研究员。曾于美国辛辛那提儿童医院访学，合作者为Qing Richard Lu教授和Yi Zheng教授.

教育：博士毕业于复旦大学生命科学学院计算生物学系，生物统计学专业，导师为田卫东教授。本科毕业于山东大学数学学院，信息安全专业，本科毕业后经保研直接攻读博士学位。

教学：Data Mining (BiUH), Programming 1 (BiUH), Data Analysis and Intro to ML (BiUH), 群体遗传学 (上交医学院), 常用生物信息学与统计学算法 (上交医学院), RNA测序数据分析 (复旦大学, 暑期学校).

科研：主要研究领域为单细胞与空间多组学算法开发及创新应用，有多年算法开发及数据分析经验。主持国自然青年项目及上海市科委扬帆计划项目，参与多个国家级、省部级项目。主要研究发表在Cell Reports、Cell Discovery、Brief Bioinform等杂志，合作研究发表在Cancer Cell、Cell Stem Cell、PNAS等杂志。

▸ 工作 & 教育

副教授 & 学科带头人，电子信息科学与技术，海南比勒费尔德应用科学大学, 中国, 2025.03 至今
副教授, 计算机科学, 海南比勒费尔德应用科学大学, 中国, 2025.02-2025.03
副研究员, 组织胚胎学与遗传发育学系, 上海交通大学医学院, 中国, 2024.01-2025.01
助理研究员, 组织胚胎学与遗传发育学系, 上海交通大学医学院, 中国, 2020.10-2023.12
访问学者, 辛辛那提儿童医院医学中心, 美国, 2018.01-2020.01. 合作者: Prof. Qing Richard Lu 和 Prof. Yi Zheng
博士, 生物统计学, 生命科学学院, 复旦大学, 中国, 2015.09-2020.06. 导师: 田卫东教授
暑期学校, 加州大学洛杉矶分校, 美国, 2013.08-2013.09. 生物统计学导论. 主讲: Prof. Gjertson, D.W.
本科, 信息安全, 数学学院, 山东大学, 中国, 2011.09-2015.06

▸ 联系方式

电子邮箱（工作）: feng.zhang@hainan-biuh.edu.cn
电子邮箱（个人）: jumphone@outlook.com
工作地址: 海南儋州洋浦经济开发区三都区西照路1号, 578001, 中国

▸ 研究论文

33 Single-cell ATAC-seq analysis of human embryoid bodies reveals crucial transcription factor networks involved in early germ layer specification, Cell & Bioscience, 2026.03, paper, co-first & co-corresponding author

32 Endogenous VEGF signaling acts as a guardian of human primed pluripotency, Nature Communications, 2026.03, paper

31 YAP-TEAD regulates the super-enhancer network to control early surface ectoderm commitment, Nucleic Acids Research, 2026.01, paper, co-corresponding author

30 Single-nucleus profiling of mouse inner ear aging uncovers cell type heterogeneity and hair cell subtype-specific age-related signatures, Cell Reports, 2025.06, paper, co-first author

29 Analysis of transcriptome and chromatin accessibility changes during the differentiation of human embryonic stem cells into neural progenitor cells, Journal of Shanghai Jiao Tong University (Medical Science), 2025.04, paper, co-corresponding author

28 A Novel Prognostic Signature of Mitophagy-Related E3 Ubiquitin Ligases in Breast Cancer, International Journal of Molecular Sciences, 2025.02, paper, co-corresponding author

27 Ultrasmall Cu2I2 nanoclusters trigger metabolic-epigenetic reprogramming and endogenous antioxidant systems for alleviating osteoarthritis, Chemical Engineering Journal, 2024.10, paper

26 ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner, BMC Biology, 2024.06, paper

25 Long-read sequencing reveals alternative splicing-driven, shared immunogenic neoepitopes regardless SF3B1 status in uveal melanoma, Cancer Immunology Research, 2023.12, paper

24 Quantitative analysis of the developmental potential of cells and tissues based on evolutionary conservation of genes and regulatory regions, Journal of Shanghai Jiao Tong University (Medical Science), 2023.11, paper, co-corresponding author

23 Feature-weight based measurement of cancerous transcriptome using cohort-wide and sample-specific information, Cellular Oncology, 2023.10, {code, paper, full-text}, corresponding author

22 Kinase-independent role of mTOR and on-/off-target effects of an mTOR kinase inhibitor, Leukemia, 2023.08, paper

21 InferLoop: leveraging single-cell chromatin accessibility for the signal of chromatin loop, Briefings in Bioinformatics, 2023.05, {code, paper}, first & co-corresponding author

20 Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability, Nature Communications, 2023.02, paper

19 Inducible lncRNA transgenic mice reveal continual role of HOTAIR in promoting breast cancer metastasis, Elife, 2022.12, paper

18 Single-cell multiomics identifies clinically relevant mesenchymal stem-like cells and key regulators for MPNST malignancy, Science Advances, 2022.11, paper

17 Conserved and Distinct Functions of the Autism-Related Chromatin Remodeler CHD8 in Embryonic and Adult Forebrain Neurogenesis, Journal of Neuroscience, 2022.11, paper

16 FitDevo: accurate inference of single-cell developmental potential using sample-specific gene weight, Briefings in Bioinformatics, 2022.09, {code, paper}, first & co-corresponding author

15 CDC42 controlled apical-basal polarity regulates intestinal stem cell to transit amplifying cell fate transition via YAP-EGF-mTOR signaling, Cell Reports, 2022.06, paper

14 scMAGIC: accurately annotating single cells using two rounds of reference-based classification, Nucleic Acids Research, 2022.05, {code, paper}, co-first author

13 OLIG2 maintenance is not essential for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes, Neuro-Oncology, 2021.11, paper

12 Single-cell transcriptomic analysis reveals a hepatic stellate cell-activation roadmap and myofibroblast origin during liver fibrosis, Hepatology, 2021.11, paper

11 Adaptive responses to mTOR gene targeting in hematopoietic stem cells reveal a proliferative mechanism evasive to mTOR inhibition, Proceedings of the National Academy of Sciences of the United States of America, 2020.12, paper

10 Unsupervised Inference of Developmental Directions for Single Cells Using VECTOR, Cell Reports, 2020.08, {code, paper}, first author

9 CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair, Nature Communications, 2020.08, paper

8 The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens, Genome Biology, 2019.11, paper

7 A novel approach to remove the batch effect of single-cell data, Cell Discovery, 2019.09, {code, paper}, first author

6 Single-Cell Transcriptomics in Medulloblastoma Reveals Tumor-Initiating Progenitors and Oncogenic Cascades during Tumorigenesis and Relapse, Cancer Cell, 2019.07, paper

5 Single-cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis, Cell Stem Cell, 2019.03, paper

4 PhenoPro: a novel toolkit for assisting in the diagnosis of Mendelian disease, Bioinformatics, 2019.02, {code, paper}, co-first author

3 Dual requirement of CHD8 for chromatin landscape establishment and histone methyltransferase recruitment to promote CNS myelination and repair, Developmental Cell, 2018.05, paper

2 SPRINT: an SNP-free toolkit for identifying RNA editing sites, Bioinformatics, 2017.07, {code, paper}, first author

1 Genome-wide identification of regulatory sequences undergoing accelerated evolution in the human genome, Molecular Biology and Evolution, 2016.07, paper